Ro Super Bowl LX Commercial ‘Healthier on Ro’ with Serena Williams
Ro is stepping onto the Super Bowl stage for the first time, and it’s doing it with one of the biggest names in sports. The direct-to-patient healthcare company is debuting its first-ever Super Bowl commercial starring GLP-1 patient ambassador Serena Williams to launch its new “Healthier on Ro” campaign. The national push spans TV, digital, and out-of-home channels and taps into the massive reach of Super Bowl advertising to spotlight GLP-1 medications, not just for weight loss but for broader health improvements.
In the Super Bowl spot, Williams talks candidly about the changes she’s seen on GLP-1s through Ro’s program. Over the past year, she’s lost 34 pounds, easing the stress on her knees and stabilizing her blood sugar. Her latest lab work shows even more dramatic gains: her total cholesterol has dropped 30% since 2021, from 185 mg/dL to 129 mg/dL—far outpacing the typical 4.8% improvement seen on GLP-1s—cutting her lifetime risk of heart disease from 27% to 8%. “I feel better now than I have in years,” Williams says, explaining that Ro helped her focus on her health in a way that fit her life and made her “feel like myself again.”
Williams first teamed up with Ro in August 2025 to share her decision to use GLP-1s, helping normalize seeking treatment and encouraging people to find out whether this class of medications might be right for them. The Super Bowl commercial builds on that story at a time when GLP-1s are available as both injections and pills, with prices lower than ever and access expanding. Ro co-founder and CEO Zach Reitano says Williams is the ideal voice to underscore that GLP-1s aren’t a shortcut but a tool, noting that “there is no one with more willpower and self-discipline than Serena Williams.” For fans tracking the evolution of celebrity-led Super Bowl commercials, it’s another high-profile example of athletes fronting health and wellness brands on the game’s biggest stage.
The broader “Healthier on Ro” campaign pairs Williams with fellow Ro GLP-1 ambassador Charles Barkley—who lost 45 pounds in seven months and reduced pressure on his knees—as well as real Ro patients whose stories mirror the non-scale victories highlighted in the ad. Featured patients include Minneapolis runner Hannah Nylander-Asplin, who lost 75 pounds in 18 months and went from struggling through a mile to finishing a marathon; Atlanta couple Deanna and Mitchell Taylor, who shed a combined 41 pounds and now have more energy to keep up with their kids; and Colorado cyclist Greg Olson, who lost 78 pounds in nine months and gained a new sense of confidence. Ro’s goal is to present these everyday patients with the same authenticity and production values as its celebrity talent, reinforcing its promise of high-quality care across the board.
“Healthier on Ro” will debut during Super Bowl LX on NBC on February 8, supported by a national media plan that includes linear and broadcast TV, paid social, and out-of-home takeovers in major U.S. cities. For brand watchers and fans of Super Bowl ads, Ro’s move signals how healthcare and weight-loss brands are increasingly investing in Super Bowl advertising alongside legacy categories like snacks, beverages, and autos. Through Ro, GLP-1 medications are prescribed for obesity and overweight, with patients typically losing 14–20% of their body weight in a year when combined with diet and exercise, and many seeing improvements in glucose levels and joint pain. As with any prescription treatment, Ro directs viewers to its safety information at ro.co/safety, while disclosure notes that Williams’ husband is an investor in the company and serves on its board.
